Example Projects

 

    2016

    • 3D Bioprinted Self-Polymerising Bacterial Bioreactors
    • CRISPR/dCas9 Synergistic Activation Mediators (SAM) as a tool for modulating gene expression in human induced pluripotent stem cells (hiPS)
    • Design and Evaluation of novel Diels-Alderases for use in Industry
    • Developing 3D Vascularized Tissues through Inputted Microchanel Flow
    • Developing synthetic biology tools to engineer the production of valuable compounds in the alga Euglena gracillis
    • Development of Biosensors for diagnosis and drug delivery in the human gut
    • Engineering Antibiotics from Abyss
    • Engineering Genetic Amplifiers
    • Engineering multistability in microbial physiology
    • Engineering new microbial rhodopsins for novel 21sat century sensor
    • Engineering receptors for optimised T cell dose responses
    • Feedback design and modelling using Srna
    • Heterologous expression and engineering of an industrially important macrolide biosynthetic pathway
    • Impact of cellular trade-offs on synthetic genetic circuits across cell populations
    • In vitro prototyping of modular polyketide synthases
    • Investigations into 3D Printed Dropet Networks
    • Learning and verifying uncertain models of Chemical Reaction
    • Molecular simulations and the Design of Gated Nanopores
    • Network to network interaction
    • Packing in 3D printed droplet networks
    • Protein Design in the cell: towards synthetic proteomes
    • Study of link between bacterial competition and diversity using 3D bacterial printing technology
    • SynBac: Synthetic Baculovirus for Next-Generation Gene Therapy
    • Synthetic Tissues from printed droplet networks
    • Towards a Comprehensive Theory of Feedback Control from Chemical Reaction Networks
    • Towards Overcoming Antimicrobial Resistance using Synthetic Biology
    • Turning immune cell reactivity using synthetic receptors

     

    2015

    • Development of reporter strains for bacterial electro-physiology
    • 3D Printing of Living Cells using Droplet Networks
    • 3D Printing of Living Cells using Droplet Networks
    • Accelerated directed evolution of proteins using phages
    • Active DNA Nanosystems in non aqueous solvents
    • Adaptive Genetic Logic Gates
    • Analogue gates for control applications
    • Artificial Ribosomes - programmable chemical synthesis using DNA templates
    • Characterising the binding properties of RNA aptamers to short peptides
    • Construction and Laboratory evolution of artificial oxidoreductases
    • Continuous Directed Evolution in MFC System     
    • Control of Cell Population and Synthetic Communities
    • Design and construction of active DNA-templates for alpha-helical barrels.
    • Designing SimCells from Cyanobacteria for the Production of Molecular Oxygen
    • Developing glycan-functionalised carbon nanodots to investigate cell type signalling during root nodulation.
    • Development of an integrated synthetic biology/chemical engineering design pipeline
    • Directed Evolution in Non-Living Systems
    • Directed evolution of artificial peroxidases
    • Dissecting noise in gene expression systems for synthetic biology
    • Engineering a synthetic gut model to explore gut microbial interactions/ Synthetic Communities
    • Engineering new DNA recognition elements using the DsdS subunit from type I restriction endonucleases
    • Engineering re-writable memory in T cells for immunotherapy
    • Evaluating the biocatalyst potential of a novel enzyme
    • Formulation and testing of Synthetic Vaccines
    • Improving gene therapy efficiency: linking Cas-9 and homologous recombination.
    • In silico simulation and analysis of gene expression variance between individual cells of a homogenous population.
    • In vitro chemical ligation of modified DNA
    • Intracellular Selex to study Stress -Related Translation
    • Investigating noise in gene expression using single molecule tracking
    • Membrane-inserting SpyCatcher for virus-like particle vaccines
    • Office adjacent to M116, School of Life Sciences.
    • On the development of synthetic cartilage
    • Re-engineering a natural Diels-Alderase for the production of new antibiotics
    • RNA-Inducible CRISPR-Cas9 transcription regulators
    • simCell Toluene Biosensor
    • Spatial organisation of enzymes using virus -like particles (VLP)
    • Synthetic Enzyme Assemblies
    • Systematic analysis of the ability of protein transduction domains to export cargo proteins from cells, and to deliver them into adjacent cells
    • Utilisation of Membrane Voltage for Synthetic Biology Genetic Circuits

     

    2014

    • 3D Printing of Bacteria
    • Applications of cell-cell communication to Synthetic Biology
    • Bioengineering red blood cells using gene editing techniques
    • Coiled-coil directed photosynthetic protein self-assemblies and programmable nano-reactor systems
    • Communication between live and synthetic cells
    • Communication between natural bacteria and artificial protocells
    • Controlling extrinsic noise in mammailiancells
    • Creating Logic-Gated Synthetic Antibodies to bring Boolean Protein to Medicine
    • Designed components for transcriptional control in cells
    • Development of SimCells as building blocks for synthetic blocks for synthetic biology
    • DNA-Templated assembly of dynamic α-helical peptide barrels
    • DNA-Templated Assembly of the Bacterial Flagellar Motor’s Torque-Generating Ring
    • Electronic interface to control cell and community metabolism
    • Embedded Cellular Controls
    • Engineering a synthetic phage
    • Engineering Logic gates in bacteria using two-component signalling
    • Engineering non-replicative bacteriophage-based payload systems for pathogen elimination.
    • Engineering Switches for Plant Growth Promotion in the Rhizosphere
    • Gene Regulatory Networks: components and control
    • Inducing Recombination in Plants Using Genome Editing Techniques
    • In-silico design of synthetic gene regularory networks for feedback control system implementation
    • Investigation of in vitro protein reconstruction directionality control
    • Light-activated gene expression for inducible communication in aqueous droplet networks
    • Measuring Molecules:Developing a Nanometre-Scale Ruler Using FRET
    • Modelling Gene Expression in a Homogenous Bacterial Population
    • Orthogonal Transcription Factors using Designed TALEs and Coliled Coils
    • Resource allocation in synthetic gene networks
    • Re-wiring plant signalling pathways to enhance stress tolerance
    • Simulation of Microbial Community in a microfluidic device
    • Synthetic  Microbial Communities
    • Synthetic Metabolons
    • Synthetically Regulated Nitrogen Fixing in Association with Cereals
    • The de novo design of coiled-coil-based transcriptional regulators
    • Using in silico approaches to design evolutionarily robust network topologies