Example Projects


 

2014

  • 3D Printing of Bacteria
  • Applications of cell-cell communication to Synthetic Biology
  • Bioengineering red blood cells using gene editing techniques
  • Coiled-coil directed photosynthetic protein self-assemblies and programmable nano-reactor systems
  • Communication between live and synthetic cells
  • Communication between natural bacteria and artificial protocells
  • Controlling extrinsic noise in mammailiancells
  • Creating Logic-Gated Synthetic Antibodies to bring Boolean Protein to Medicine
  • Designed components for transcriptional control in cells
  • Development of SimCells as building blocks for synthetic blocks for synthetic biology
  • DNA-Templated assembly of dynamic α-helical peptide barrels
  • DNA-Templated Assembly of the Bacterial Flagellar Motor’s Torque-Generating Ring
  • Electronic interface to control cell and community metabolism
  • Embedded Cellular Controls
  • Engineering a synthetic phage
  • Engineering Logic gates in bacteria using two-component signalling
  • Engineering non-replicative bacteriophage-based payload systems for pathogen elimination.
  • Engineering Switches for Plant Growth Promotion in the Rhizosphere
  • Gene Regulatory Networks: components and control
  • Inducing Recombination in Plants Using Genome Editing Techniques
  • In-silico design of synthetic gene regularory networks for feedback control system implementation
  • Investigation of in vitro protein reconstruction directionality control
  • Light-activated gene expression for inducible communication in aqueous droplet networks
  • Measuring Molecules:Developing a Nanometre-Scale Ruler Using FRET
  • Modelling Gene Expression in a Homogenous Bacterial Population
  • Orthogonal Transcription Factors using Designed TALEs and Coliled Coils
  • Resource allocation in synthetic gene networks
  • Re-wiring plant signalling pathways to enhance stress tolerance
  • Simulation of Microbial Community in a microfluidic device
  • Synthetic  Microbial Communities
  • Synthetic Metabolons
  • Synthetically Regulated Nitrogen Fixing in Association with Cereals
  • The de novo design of coiled-coil-based transcriptional regulators
  • Using in silico approaches to design evolutionarily robust network topologies

2015

  • Development of reporter strains for bacterial electro-physiology
  • 3D Printing of Living Cells using Droplet Networks
  • 3D Printing of Living Cells using Droplet Networks
  • Accelerated directed evolution of proteins using phages
  • Active DNA Nanosystems in non aqueous solvents
  • Adaptive Genetic Logic Gates
  • Analogue gates for control applications
  • Artificial Ribosomes - programmable chemical synthesis using DNA templates
  • Characterising the binding properties of RNA aptamers to short peptides
  • Construction and Laboratory evolution of artificial oxidoreductases
  • Continuous Directed Evolution in MFC System     
  • Control of Cell Population and Synthetic Communities
  • Design and construction of active DNA-templates for alpha-helical barrels.
  • Designing SimCells from Cyanobacteria for the Production of Molecular Oxygen
  • Developing glycan-functionalised carbon nanodots to investigate cell type signalling during root nodulation.
  • Development of an integrated synthetic biology/chemical engineering design pipeline
  • Directed Evolution in Non-Living Systems
  • Directed evolution of artificial peroxidases
  • Dissecting noise in gene expression systems for synthetic biology
  • Engineering a synthetic gut model to explore gut microbial interactions/ Synthetic Communities
  • Engineering new DNA recognition elements using the DsdS subunit from type I restriction endonucleases
  • Engineering re-writable memory in T cells for immunotherapy
  • Evaluating the biocatalyst potential of a novel enzyme
  • Formulation and testing of Synthetic Vaccines
  • Improving gene therapy efficiency: linking Cas-9 and homologous recombination.
  • In silico simulation and analysis of gene expression variance between individual cells of a homogenous population.
  • In vitro chemical ligation of modified DNA
  • Intracellular Selex to study Stress -Related Translation
  • Investigating noise in gene expression using single molecule tracking
  • Membrane-inserting SpyCatcher for virus-like particle vaccines
  • Office adjacent to M116, School of Life Sciences.
  • On the development of synthetic cartilage
  • Re-engineering a natural Diels-Alderase for the production of new antibiotics
  • RNA-Inducible CRISPR-Cas9 transcription regulators
  • simCell Toluene Biosensor
  • Spatial organisation of enzymes using virus -like particles (VLP)
  • Synthetic Enzyme Assemblies
  • Systematic analysis of the ability of protein transduction domains to export cargo proteins from cells, and to deliver them into adjacent cells
  • Utilisation of Membrane Voltage for Synthetic Biology Genetic Circuits

2016

  • 3D Bioprinted Self-Polymerising Bacterial Bioreactors
  • CRISPR/dCas9 Synergistic Activation Mediators (SAM) as a tool for modulating gene expression in human induced pluripotent stem cells (hiPS)
  • Design and Evaluation of novel Diels-Alderases for use in Industry
  • Developing 3D Vascularized Tissues through Inputted Microchanel Flow
  • Developing synthetic biology tools to engineer the production of valuable compounds in the alga Euglena gracillis
  • Development of Biosensors for diagnosis and drug delivery in the human gut
  • Engineering Antibiotics from Abyss
  • Engineering Genetic Amplifiers
  • Engineering multistability in microbial physiology
  • Engineering new microbial rhodopsins for novel 21sat century sensor
  • Engineering receptors for optimised T cell dose responses
  • Feedback design and modelling using Srna
  • Heterologous expression and engineering of an industrially important macrolide biosynthetic pathway
  • Impact of cellular trade-offs on synthetic genetic circuits across cell populations
  • In vitro prototyping of modular polyketide synthases
  • Investigations into 3D Printed Dropet Networks
  • Learning and verifying uncertain models of Chemical Reaction
  • Molecular simulations and the Design of Gated Nanopores
  • Network to network interaction
  • Packing in 3D printed droplet networks
  • Protein Design in the cell: towards synthetic proteomes
  • Study of link between bacterial competition and diversity using 3D bacterial printing technology
  • SynBac: Synthetic Baculovirus for Next-Generation Gene Therapy
  • Synthetic Tissues from printed droplet networks
  • Towards a Comprehensive Theory of Feedback Control from Chemical Reaction Networks
  • Towards Overcoming Antimicrobial Resistance using Synthetic Biology
  • Turning immune cell reactivity using synthetic receptors

2017

  • Molecules and Origins of Life
  • Rotary Molecular Motors
  • Synthetic Tissues from printed droplets networks
  • Gentically engineering machines for intelligent cell stimulation and early warning
  • Engineering new microbial rhodopsins for novel 21st century sensor materials for broad- banded , molecular scale wavelength selective detectopm/ Synthetic Biology
  • Synthetic reconstitution of mitotic switch
  • Development of encapsulated biosensors for diagnosis and drug delivery in human gut
  • DNA Nanostructures
  • Towards Overcoming Antimicrobial Resistance Using Synthetic Biology/ Schofield Group Research
  • Developing Synthetic Biology tools to engineer the production of valuable compound in the alga Euglena gracillis
  • Engineering gentic amplifiers for the detection of carcingogens in human gut
  • Molecular Simulation and Design of Gated Nanopores
  • Re-engineering photosynthesis for improved crop yield
  • Development of SimCells as smart bioparticles under control of aspirin
  • The design of DNA nanostructures using computational techniques
  • Microbial Social Evolution
  • Shaping the steady-state behaviour of a biological model
  • Feedback design and modeling using post-transcriptional regulation
  • Network-to Nework interaction
  • Understanding and engineering microbial communities 
  • Precise reduction of models of chemical reaction networks
  • Real Time Broadcast control of gene expression of a population of cells
  • Rewiring T cells for dose discrimination using synthetic receptors